Presence of anaplastic lymphoma kinase in inflammatory breast cancer
نویسندگان
چکیده
منابع مشابه
Expression of Anaplastic Lymphoma Kinase Protein in Human Breast Cancer
Background & Objectives: Anaplastic lymphoma Kinase (ALK) is a receptor tyrosine kinase involved in the genesis of several human cancers. ALK was initially identified because of its involvement in anaplastic large cell lymphoma (ALCL). ALK is believed to foster tumorigenesis following activation by autocrine and/or paracrine growth loops. Studies reveal that the presence of anti-ALK antibodies ...
متن کاملPresence of anaplastic lymphoma kinase in inflammatory breast cancer
Although Inflammatory Breast Cancer (IBC) is recognized as the most metastatic variant of locally advanced breast cancer, the molecular basis for the distinct clinical presentation and accelerated program of metastasis of IBC is unknown. Reverse phase protein arrays revealed activation of the receptor tyrosine kinase, anaplastic lymphoma kinase (ALK) and biochemically-linked downstream signalin...
متن کاملexpression of anaplastic lymphoma kinase protein in human breast cancer
background & objectives: anaplastic lymphoma kinase (alk) is a receptor tyrosine kinase involved in the genesis of several human cancers. alk was initially identified because of its involvement in anaplastic large cell lymphoma (alcl). alk is believed to foster tumorigenesis following activation by autocrine and/or paracrine growth loops. studies reveal that the presence of anti-alk antibod...
متن کاملTargeting anaplastic lymphoma kinase in lung cancer.
Several decades of cancer research have revealed a pivotal role for tyrosine kinases as key regulators of signaling pathways, controlling cell growth and differentiation. Deregulation of tyrosine kinase-mediated signaling occurs frequently in cancer and is believed to drive the initiation and progression of disease. Chromosomal rearrangements involving the tyrosine kinase anaplastic lymphoma ki...
متن کاملStatus of the anaplastic lymphoma kinase (ALK) gene in inflammatory breast carcinoma
BACKGROUND Although preliminary reports suggest that ALK gene amplification may occur in inflammatory breast cancer (IBC), data are limited. We performed a comprehensive investigation of the status of ALK gene in IBC. METHODS We used core biopsy (CB) samples from 30 IBC patients for immunohistochemistry (IHC), 25 of these samples for fluorescence in situ hybridization (FISH) of ALK gene rearr...
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ژورنال
عنوان ژورنال: SpringerPlus
سال: 2013
ISSN: 2193-1801
DOI: 10.1186/2193-1801-2-497